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The Drumlish Road, just outside Omagh, has been closed off to the public and police are attending the scene.
A cordon has been drawn across the Drumlish road, which runs near Omagh, Dromore and Drumquin, and a number of police officers are present.
The PSNI are yet to disclose the reason for the sudden closure, however, there have been reports that it is in response to a serious incident.
Motorists are advised to avoid the area if possible.
Updates will be published as the situation develops.